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Thyrotropin-Releasing Hormone (TRH), Free Acid

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Purity:98%

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COA HNMR

Thyrotropin-Releasing Hormone (TRH), Free Acid

Catalog No. T7407Cas No. 24769-58-2

Thyrotropin-Releasing Hormone (TRH), Free Acid (TRH-OH) (TRH-OH) causes a variety of thyroidal and non-thyroidal effects, the best known being the feedback regulation of thyroid hormone levels.

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Pack Size	Price	Availability
5 mg	$46	In Stock
10 mg	$74	In Stock
25 mg	$115	In Stock
50 mg	$156	In Stock
100 mg	$238	In Stock
1 mL x 10 mM (in DMSO)	$63	In Stock

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Product Introduction

Bioactivity

Description	Thyrotropin-Releasing Hormone (TRH), Free Acid (TRH-OH) (TRH-OH) causes a variety of thyroidal and non-thyroidal effects, the best known being the feedback regulation of thyroid hormone levels.
In vitro	Thyrotropin-releasing-hormone (TRH) stimulated the release of newly synthesized GH and PRL, but not thyroid-stimulating hormone. In addition, TRH stimulated a dose-related increase in the release of newly synthesized GH and PRL at 10(-9) to 10(-7) M. Cyclo(His-Pro) stimulated the release of newly synthesized GH dose- dependently. TRH, cyclo(His-Pro), and hGHRH stimulated GH synthesis, while SRIF inhibited this at 10(-7) M. The release of newly synthesized PRL into culture medium was also stimulated by TRH and hGHRH, but inhibited by SRIF. PRL synthesis was not affected by TRH-OH and cyclo(His-Pro). Intracellular contents of GH and PRL in the pituitary did not change significantly.TRH plays an important role in both GH and PRL synthesis and release[1].
Alias	TRH-OH

Chemical Properties

Molecular Weight	363.37
Formula	C16H21N5O5
Cas No.	24769-58-2

Storage & Solubility Information

Storage

keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 11 mg/mL (30.27 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7520 mL	13.7601 mL	27.5202 mL	137.6008 mL
5 mM	0.5504 mL	2.7520 mL	5.5040 mL	27.5202 mL
10 mM	0.2752 mL	1.3760 mL	2.7520 mL	13.7601 mL
20 mM	0.1376 mL	0.6880 mL	1.3760 mL	6.8800 mL

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